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Molecular Basis of Inheritance question

2023 · Q60
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Molecular Basis of Inheritance question

2023 · Q60

NEETBiologyMolecular Basis of InheritanceMCQ+4 / −1

Select the correct statements about sickle cell anaemia.

(A) There is a change in gene for beta globin.

(B) In the beta globin, there is valine in the place of Lysine.

(C) It is an example of point mutation.

(D) In the normal gene U is replaced by A.

Choose the correct answer from the options given below :

  1. A
    (B), (C) and (D) only
  2. B
    (B) and (D) only
  3. C
    (A), (B) and (D) only
  4. D
    (A) and (C) only
View written solutionFree

Correct answer: D

Sickle cell anemia is caused by a single point mutation in the gene for the beta globin chain of hemoglobin.

(A) is correct because the mutation occurs in the gene for beta globin.

(B) is incorrect because, in sickle cell anemia, there is a change in the beta globin chain where valine is substituted for glutamic acid, not lysine.

(C) is correct because sickle cell anemia is caused by a single point mutation, which is a change in a single nucleotide in the DNA.

(D) is incorrect because the statement does not accurately describe the genetic mutation. In the normal gene, the DNA code is GAG, which codes for glutamic acid, but in sickle cell anemia, this is changed to GTG, which codes for valine. This does not involve replacing uracil (U) with adenine (A) as the statement suggests.

So, the correct answer is Option D : (A) and (C) only.

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