The question asks which statement is incorrect with respect to the metaphase stage of cell division.

Option D is incorrect because metaphase chromosomes are not made up of four sister chromatids held together by the centromere. Instead, metaphase chromosomes consist of two sister chromatids held together by the centromere. The sister chromatids are identical copies of a single chromosome that have been replicated during the S phase of the cell cycle.

Now, let's look at the other options, which are correct :

Option A : Chromosomes lie at the equator of the cell - During metaphase, the chromosomes align along the equatorial plane (also known as the metaphase plate) in the middle of the cell. This arrangement ensures that each daughter cell will receive an equal number of chromosomes during cell division.

Option B : Complete disintegration of the nuclear envelope takes place - In both mitosis and meiosis, the nuclear envelope breaks down during prophase and is completely disintegrated by the time the cell reaches metaphase. This allows the spindle fibers to attach to the chromosomes and facilitate their alignment at the equator.

Option C : Chromosomes are highly condensed - During metaphase, the chromosomes are at their highest level of condensation, which allows them to be more easily visualized under a microscope. This condensation also aids in the proper alignment and segregation of chromosomes during cell division.