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Biomolecules question

2025 · 4 Apr · Shift 1 · Q18
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Biomolecules question

2025 · 4 Apr · Shift 1 · Q18

JEE MainChemistryBiomoleculesMCQ+4 / −1
Identify the pair of reactants that upon reaction, with elimination of HCl will give rise to the dipeptide Gly-Ala.
  1. A
    JEE Main 2025 (Online) 4th April Morning Shift Chemistry - Biomolecules Question 3 English Option 1
  2. B
    JEE Main 2025 (Online) 4th April Morning Shift Chemistry - Biomolecules Question 3 English Option 2
  3. C
    JEE Main 2025 (Online) 4th April Morning Shift Chemistry - Biomolecules Question 3 English Option 3
  4. D
    JEE Main 2025 (Online) 4th April Morning Shift Chemistry - Biomolecules Question 3 English Option 4
View written solutionFree

Correct answer: C

  1. What is the target dipeptide?

    The dipeptide Gly-Ala means:

    • the N-terminal amino acid is glycine: H2N−CH2−COOH\mathrm{H_2N-CH_2-COOH}H2​N−CH2​−COOH
    • the C-terminal amino acid is alanine: H2N−CH(CH3)−COOH\mathrm{H_2N-CH(CH_3)-COOH}H2​N−CH(CH3​)−COOH

    So the peptide formed is: H2N−CH2−CO−NH−CH(CH3)−COOH\mathrm{H_2N-CH_2-CO-NH-CH(CH_3)-COOH}H2​N−CH2​−CO−NH−CH(CH3​)−COOH

  2. How is a peptide bond formed?

    A peptide bond is formed between:

    • the carboxyl group of the first amino acid, and
    • the amino group of the second amino acid.

    For Gly-Ala, the bond must form as: Gly−CO−NH−Ala\mathrm{Gly-CO-NH-Ala}Gly−CO−NH−Ala

  3. Why does the question mention elimination of HCl?

    Elimination of HCl\mathrm{HCl}HCl suggests that one reactant must provide:

    • an acid chloride group (−COCl)(-\mathrm{COCl})(−COCl), and
    • the other reactant must provide an amino group (−NH2)(-\mathrm{NH_2})(−NH2​).

    Thus, to obtain Gly-Ala, we need:

    • glycine acid chloride at the carboxyl end, and
    • alanine with free amino group.
  4. Required reactants

    The correct pair should therefore be: H2N−CH2−COClandH2N−CH(CH3)−COOH\mathrm{H_2N-CH_2-COCl} \quad \text{and} \quad \mathrm{H_2N-CH(CH_3)-COOH}H2​N−CH2​−COClandH2​N−CH(CH3​)−COOH

    On reaction: H2N−CH2−COCl+H2N−CH(CH3)−COOH→H2N−CH2−CO−NH−CH(CH3)−COOH+HCl\mathrm{H_2N-CH_2-COCl + H_2N-CH(CH_3)-COOH} \rightarrow \mathrm{H_2N-CH_2-CO-NH-CH(CH_3)-COOH + HCl}H2​N−CH2​−COCl+H2​N−CH(CH3​)−COOH→H2​N−CH2​−CO−NH−CH(CH3​)−COOH+HCl

    This gives the dipeptide Gly-Ala.

  5. Comparison with stored answer

    The stored correct answer is C. Since the correct choice must be the option containing glycine acid chloride + alanine, this matches C.

Final Answer: C\boxed{\text{C}}C​

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