JEE AdvancedChemistryBiomoleculesNumerical+4 / −1
For a double strand DNA, one strand is given below:
The amount of energy required to split the double strand DNA into two single strands is kcal . [Given: Average energy per H-bond for A-T base pair , G-C base pair , and A-U base pair . Ignore electrostatic repulsion between the phosphate groups.]
The amount of energy required to split the double strand DNA into two single strands is kcal . [Given: Average energy per H-bond for A-T base pair , G-C base pair , and A-U base pair . Ignore electrostatic repulsion between the phosphate groups.]Numerical answer
View written solutionFree
Correct answer: 41
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Principle used
In double-stranded DNA:
- pairs with through 2 H-bonds
- pairs with through 3 H-bonds
The question directly gives average energy contribution per H-bonded base pair:
- For one pair: per H-bond, so
- For one pair: per H-bond, so
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Count the bases in the given strand
From the given DNA strand, the total number of:
- type base pairs
- type base pairs
Hence, on forming the complementary strand, the double-stranded DNA contains:
- pairs
- pairs
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Calculate total energy required to separate the strands
Total energy is the sum of energies of all base pairs:
Substituting values:
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Integer answer
Since the answer type is integer, we take the nearest integer:
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Comparison with stored answer
Stored correct answer is , but the calculated value is based on standard DNA pairing energetics and the stated data.
Therefore, I do not agree with the stored answer.
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