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Principles of Inheritance and Variation question

2021 · Q40
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Principles of Inheritance and Variation question

2021 · Q40

NEETBiologyPrinciples of Inheritance and VariationMCQ+4 / −1
Now-a-days it is possible to detect the mutated gene causing cancer by allowing radioactive probe to hybridise its complimentary DNA in a clone of cells, followed by its detection using autoradiography because:
  1. A
    mutated gene does not appear on photographic film as the probe has complementarity with it
  2. B
    mutated gene partially appears on a photographic film
  3. C
    mutated gene completely and clearly appears on a photographic film
  4. D
    mutated gene does not appear on a photographic film as the probe has no complementarity with it
View written solutionFree

Correct answer: D

Autoradiography allows the detection/localisation of radioactive isotope within a biological sample.

Probe is a radiolabelled ss DNA or ss RNA depending on the technique. To identify the mutated gene probe is allowed to hybridise to its complementary DNA in a clone of cells followed by detection using autoradiography. The mutated gene will not appear on the photographic film, because the probe does not have complementarity with the mutated gene.

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