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Principles of Inheritance and Variation question

2009 · Q68
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Principles of Inheritance and Variation question

2009 · Q68

NEETBiologyPrinciples of Inheritance and VariationMCQ+4 / −1
Sickle-cell anemia is :
  1. A
    Caused by substitute of valine by glutamic acid in the beta globin chain of haemoglobin
  2. B
    An autosomal linked dominant trait
  3. C
    Caused by a change in a single base pair of DNA
  4. D
    Characterized by elongated sickle like RBCs with a nucleus
View written solutionFree

Correct answer: C

Sickle-cell anaemia is an autosomal hereditary disorder in which erythrocytes become sickle shaped. It is caused by the formation of abnormal haemoglobin called haemoglobin-S. Haemoglobin-S is formed when 6th amino acid of β\beta β-chain, i.e., glutamic acid is replaced by valine due to substitution. It occurs due to a single nucleotide change (A →\to→ T) in the β\beta β-globin gene of coding strand. In the normal β\beta β-globin gene the DNA sequence is CCTGAGGAG, while in sicklecell anaemia, the sequence is CCTGTGGAG.

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