To solve this matching problem, we need to pair each item from List - I with the corresponding item in List - II. Let's analyze each pair:

(A) Malignant tumors - Malignant tumors are characterized by uncontrolled growth and the ability to invade or spread to other parts of the body. This process is known as Metastasis.

(B) MALT - MALT stands for Mucosa-Associated Lymphoid Tissue. It is a part of the immune system that includes tissues such as the tonsils and the Peyer's patches in the intestines. Therefore, it is associated with Lymphoid tissue.

(C) NACO - NACO stands for the National AIDS Control Organization, which is involved in the fight against AIDS in India. Thus, it relates to AIDS.

(D) $\alpha$-Interferons - $\alpha$-Interferons are a group of signaling proteins used in the treatment of various diseases, including some cancers, by helping the immune system destroy tumors. Therefore, they are connected to the action to Destroy tumors.

Now, let's match these correctly:

• (A) Malignant tumors - (III) Metastasis
• (B) MALT - (IV) Lymphoid tissue
• (C) NACO - (II) AIDS
• (D) $\alpha$-Interferons - (I) Destroy tumors

Thus, the correct option is:

Option A: A-III, B-IV, C-II, D-I

Therefore, the answer is: Option A