Entamoeba histolytica is a parasitic protozoan that causes amoebiasis. It primarily affects the colon, where it can cause a range of symptoms from mild diarrhea to severe dysentery. The active, trophozoite form of Entamoeba histolytica feeds on various components in the colon.

The correct answer is:

Option D: erythrocytes, mucosa and submucosa of colon

This is because the trophozoites of Entamoeba histolytica invade the mucosal lining of the colon, leading to ulceration and tissue destruction. They feed on the mucosa and submucosa tissues. Additionally, the trophozoites can ingest erythrocytes (red blood cells), which contribute to their growth and proliferation.

The trophozoite stage is particularly harmful because it can cause significant damage to the host tissues, leading to clinical symptoms and complications associated with amoebiasis.